ASSOCIATION BETWEEN VITAMIN D-BINDING PROTEIN (VDBP) GENE POLYMORPHISM AND VITAMIN D STATUS IN YOUNG CHILDREN

Is there any association between a vitamin D receptor gene polymorphism (FokI) and pemphigus vulgaris?

Background: Pemphigus vulgaris (PV) is an autoimmune bullous disease of the skin and mucous membranes caused by activation and proliferation of T cells, production of Th2 cytokine profile and pathogenic antibodies. Vitamin D is a probable immunodeviator to Th2, which its actions are mediated through the vitamin D receptor (VDR). FokI is the only single nucleot...

Association between the vitamin D receptor gene polymorphism and osteoporosis.

The influence of the vitamin D receptor (VDR) gene for the risk of osteoporosis remains to be elucidated. The aim of the present study was to understand the distribution of various single-nucleotide polymorphisms (SNPs) within the VDR gene and its association with the risk of osteoporosis. In total, 378 subjects without a genetic relationship were recruited to the study between January 2013 and...

Association between vitamin D receptor gene polymorphism and Alzheimer's disease.

Vitamin D(3) is known to be involved in neuroprotection and exert its neuroprotective effects by modulating neuronal calcium homeostasis and production of neurotrophins. The single nucleotide polymorphisms (SNP) in vitamin D receptor (VDR) gene which can influence the affinity of vitamin D(3) to its receptor may be related to neurodegenerative diseases and neuronal damage by altering the vitami...

Vitamin D Status and Its Association with Attention Deficit Hyperactivity Disorder (ADHD) in Children

The variation in free 25-hydroxy vitamin D and vitamin D-binding protein with season and vitamin D status

PURPOSE Serum 25-hydroxy vitamin D [25(OH)D] varies greatly with season at northern latitudes. The purpose of this study was to determine if the seasonal variations in serum total 25(OH)D are followed by a concomitant variation in free 25(OH)D or if the variation is damped by alterations in the binding capacity of DBP. METHODS Serum was collected from 540 healthy blood donors (60% men; mean a...